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Article

A Dynamic Picture of the Early Events in Nociceptin Binding to the NOP Receptor by Metadynamics.

Biophysical journal - 20 Sept 2016

Della Longa Stefano, Arcovito Alessandro

Abstract excerpt

Nociceptin (NCC, also known as FQ (N/OFQ)) is the 17-amino acid neuropeptide, endogenous ligand for the G-protein-coupled receptor (NOP, also known as ORL-1). In this study, starting from the recently reported x-ray structure at pH 7 of NOP in complex with an antagonist, new insights, to our knowledge, on the binding geometry of NCC to NOP have been provided in silico. After a rigid docking of NCC in an α-helix...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27653479
DOI: 10.1016/j.bpj.2016.07.004
PMCID: PMC5034302

Genes

FES

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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