Molecular insights into ZER1 recognition of N-terminal residue mutations.

Abstract excerpt

N-terminal glycine (Gly/N-degron), as a degradation signal, can be recognized by specific E3 ubiquitin ligases and plays a crucial role in protein degradation and cellular homeostasis. As a substrate receptor in the Cullin 2-RING E3 ligase complex, ZER1 mediates protein degradation via the Gly/N-degron pathway by recognizing N-terminal glycine and other small residues. This study employed all-atom molecular...

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