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Article

Structural modelling and mutation analysis of a nociceptin receptor and its ligand complexes.

Journal of biochemistry - 1 Jun 2007

Akuzawa Natsuyo, Takeda Shigeki, Ishiguro Masaji

Abstract excerpt

We recently modelled and proposed four ligand-bound conformations for a G-protein-coupled receptor, namely, forms I, II, III and IV, based on the 3D structure and functional evidences for rhodopsin. In this study, the same strategy was applied to a human nociceptin receptor (NR), in order to predict ligand-bound receptor structures. Additionally, site-directed mutagenesis studies were carried out to evaluate...

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Identifiers

PMID: 17456499
DOI: 10.1093/jb/mvm100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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