Article
An ACACB variant implicated in diabetic nephropathy associates with body mass index and gene expression in obese subjects.
PloS one - 1 Jan 2013
Ma Lijun, Murea Mariana, Snipes James A, Marinelarena Alejandra, Krüger Jacqueline, Hicks Pamela J, Langberg Kurt A, Bostrom Meredith A, Cooke Jessica N, Suzuki Daisuke, Babazono Tetsuya, Uzu Takashi, Tang Sydney C W, Mondal Ashis K, Sharma Neeraj K, Kobes Sayuko, Antinozzi Peter A, Davis Matthew, Das Swapan K, Rasouli Neda, Kern Philip A, Shores Nathan J, Rudel Lawrence L, Blüher Matthias, Stumvoll Michael, Bowden Donald W, Maeda Shiro, Parks John S, Kovacs Peter, Hanson Robert L, Baier Leslie J, Elbein Steven C, Freedman Barry I
Abstract excerpt
Acetyl coenzyme A carboxylase B gene (ACACB) single nucleotide polymorphism (SNP) rs2268388 is reproducibly associated with type 2 diabetes (T2DM)-associated nephropathy (DN). ACACB knock-out mice are also protected from obesity. This study assessed relationships between rs2268388, body mass index (BMI) and gene expression in multiple populations, with and without T2DM. Among subjects without T2DM, rs2268388 DN...
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