Sodium Butyrate Ameliorates Diabetic Kidney Disease Partially Through ACSS2/P300-Mediated Histone Butyrylation Pathway

Abstract excerpt

<title>Abstract</title> <p>Background: Studies suggest that sodium butyrate (NaB) can ameliorate glucose and lipid metabolism, as well as renal damage in dabetic kidney disease (DKD) mice, potentially through histone post-translational modifications. Histone butyrylation, an acylation modification induced by butyrate, is facilitated by acetyl-CoA synthetase 2 (ACSS2) and P300. However, the precise role and mechan...

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• Autophagy in Disease and Therapy
• Diet and metabolism studies
• Epigenetics and DNA Methylation
• Histone Deacetylase Inhibitors Research
• Metabolism, Diabetes, and Cancer
• Pancreatic function and diabetes
• Peptidase Inhibition and Analysis
• RNA modifications and cancer

Identifiers and source

Literature Corpus work

27ba9c82-db40-5a42-8a80-932596d8772d

DOI

10.21203/rs.3.rs-7519371/v1