Article
Association of the PGC-1α rs8192678 variant with microalbuminuria in subjects with type 2 diabetes mellitus.
Disease markers - 1 Jan 2012
Prior Sarah L, Clark Amy R, Jones Danielle A, Bain Steve C, Hurel Steve J, Humphries Steve E, Stephens Jeffrey W
Abstract excerpt
PPAR-γ co-activator-1α (PGC-1α) is a tissue-specific transcriptional co-activator involved in the regulation of antioxidant enzymes. The A-allele of the rs8192678 PGC-1 α} (G>A) gene variant has previously been associated with nephropathy in Korean and Indian-Asian type 2 diabetes mellitus (T2DM) samples. Our aim was to examine the association between this variant and urine albumin exccretion in European subjects...
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