Article
A single nucleotide polymorphism within the acetyl-coenzyme A carboxylase beta gene is associated with proteinuria in patients with type 2 diabetes.
PLoS genetics - 12 Feb 2010
Maeda Shiro, Kobayashi Masa-aki, Araki Shin-ichi, Babazono Tetsuya, Freedman Barry I, Bostrom Meredith A, Cooke Jessica N, Toyoda Masao, Umezono Tomoya, Tarnow Lise, Hansen Torben, Gaede Peter, Jorsal Anders, Ng Daniel P K, Ikeda Minoru, Yanagimoto Toru, Tsunoda Tatsuhiko, Unoki Hiroyuki, Kawai Koichi, Imanishi Masahito, Suzuki Daisuke, Shin Hyoung Doo, Park Kyong Soo, Kashiwagi Atsunori, Iwamoto Yasuhiko, Kaku Kohei, Kawamori Ryuzo, Parving Hans-Henrik, Bowden Donald W, Pedersen Oluf, Nakamura Yusuke
Abstract excerpt
It has been suggested that genetic susceptibility plays an important role in the pathogenesis of diabetic nephropathy. A large-scale genotyping analysis of gene-based single nucleotide polymorphisms (SNPs) in Japanese patients with type 2 diabetes identified the gene encoding acetyl-coenzyme A carboxylase beta (ACACB) as a candidate for a susceptibility to diabetic nephropathy; the landmark SNP was found in the...
Topics
- Acetyl-CoA Carboxylase
- Adult
- Animals
- Base Pairing
- Base Sequence
- Case-Control Studies
- Cells, Cultured