Article
ACACβ gene (rs2268388) and AGTR1 gene (rs5186) polymorphism and the risk of nephropathy in Asian Indian patients with type 2 diabetes.
Molecular and cellular biochemistry - 1 Jan 2013
Shah Viral N, Cheema Balneek Singh, Sharma Rajni, Khullar Madhu, Kohli Harbir Singh, Ahluwalia Tarunveer Singh, Mohan Viswanathan, Bhansali Anil
Abstract excerpt
Patients with type 2 diabetes (T2DM) are usually obese and concurrent obesity results into activation of the renin-angiotensin-system (RAS) which is a risk factor for diabetic nephropathy (DN). Gene-gene interaction between acetyl-coenzymeA carboxylase beta (ACACβ) gene, which is involved in fatty acid metabolism and angiotensin II receptors (AGTR1) gene, which mediates RAS proteins actions on renal tissue,...
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