Article
Alpha-Ca2+/calmodulin-dependent protein kinase II contributes to the developmental programming of anxiety in serotonin receptor 1A knock-out mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 11 Jun 2008
Lo Iacono Luisa, Gross Cornelius
Abstract excerpt
Mice lacking the serotonin receptor 1A [Htr1aknock-out (Htr1a(KO))] display increased innate and conditioned anxiety-related behavior. Expression of the receptor in the mouse forebrain during development is sufficient to restore normal anxiety-related behavior to knock-out mice, demonstrating a role for serotonin in the developmental programming of anxiety circuits. However, the precise developmental period as...
Topics
- Actins
- Alanine
- Analysis of Variance
- Animals
- Animals, Newborn
- Anxiety
- Behavior, Animal
- Calcium-Calmodulin-Dependent Protein Kinase Type 2
- Disks Large Homolog 4 Protein
- Exploratory Behavior
- Guanylate Kinases
- Hippocampus
- Hypothermia, Induced