Hippocampal Cofilin and CFL1 gene variants are linked to Alcohol Use Disorder phenotypes.

doi:10.1038/s41380-025-03226-3

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Hippocampal Cofilin and CFL1 gene variants are linked to Alcohol Use Disorder phenotypes.

Molecular psychiatry - 1 Mar 2026

Salamian Ahmad, Pagano Roberto, Skonieczna Edyta, Kalinichenko Liubov S, Puchalska Monika, Yiğit Ünlü G, Gajewska-Woźniak Olga, Kruashvili Lali, Grochowicz Małgorzata, Wojtas Bartosz, Gielniewski Bartek, Harda Zofia, Cały Anna, Mühle Christiane, Lenz Bernd, Kornhuber Johannes, Lourdusamy Anbarasu, Havekes Robbert, Abel Ted, Müller Christian P, Radwanska Kasia

Abstract excerpt

Alcohol use disorder (AUD) is characterized by pathological motivation to consume alcohol and cognitive inflexibility, leading to excessive alcohol seeking and use. In this study, we investigated the molecular correlates of impaired extinction of alcohol seeking during forced abstinence using a mouse model of AUD in the automated IntelliCage social system. This model distinguished AUD-prone and AUD-resistant...

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PMID: 40931167
DOI: 10.1038/s41380-025-03226-3
PMCID: PMC12916304

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CFL1

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