Article

A polygenic predictor of baseline QTc is associated with sotalol-induced QT prolongation

2024-05-03

Abstract excerpt

<h4>Background</h4> Drug-induced QT interval prolongation raises the risk of fatal arrhythmia and is a central issue in safety pharmacology. Yet individual QT drug response is highly variable, and risk stratification remains a challenge. We hypothesized that genetic factors underlying the baseline QT influence this variation in QT drug response. <h4>Methods</h4> A cohort of 990 healthy subjects was prospectively c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 177b1299-6b0e-5cc0-8bb4-61c9ccbfd332
DOI: 10.1101/2024.05.01.24306714

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A polygenic predictor of baseline QTc is associated with sotalol-induced QT prolongationDOI 10.1101/2024.05.01.24306714Read

GENomE wide analysis of sotalol-induced IKr inhibition during ventricular REPOLarization, "GENEREPOL study": Lack of common variants with large effect sizes.Semantic proximity Read

Common Genetic Variant Risk Score Is Associated With Drug-Induced QT Prolongation and Torsade de Pointes Risk: A Pilot Study.Semantic proximity Read

Modeling susceptibility to drug-induced long QT with a panel of subject-specific induced pluripotent stem cellsSemantic proximity Read

Polygenic Risk Score predicts QTc-prolongation and Short-Term Mortality in Patients using QT-prolonging Psychoactive MedicationsSemantic proximity Read

Association of the NOS1AP rs10494366 Genetic Variant With Drug-Induced QT Prolongation.Semantic proximity Read

Pharmacogenetics of Drug-Induced QT Interval Prolongation: An Update.Semantic proximity Read

Genetic and Molecular Aspects of Drug-Induced QT Interval ProlongationSemantic proximity Read

Genome wide analysis of drug-induced torsades de pointes: lack of common variants with large effect sizes.Semantic proximity Read

Monogenic and Polygenic Contributions to QTc Prolongation in the PopulationSemantic proximity Read

Drug‐ and non‐drug‐associated QT interval prolongationSemantic proximity Read

Genetic Investigation of Corrected QT Interval Sensitivity to Oral Bepridil Hydrochloride Hydrate in Patients With Atrial Fibrillation.Semantic proximity Read

Impacts of gene variants on drug effects-the foundation of genotype-guided pharmacologic therapy for long QT syndrome and short QT syndrome.Semantic proximity Read