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Article

Examination of rare missense variants in the CHRNA5-A3-B4 gene cluster to level of response to alcohol in the San Diego Sibling Pair study.

Alcoholism, clinical and experimental research - 1 Aug 2013

Choquet Hélène, Joslyn Geoff, Lee Andrew, Kasberger Jay, Robertson Margaret, Brush Gerry, Schuckit Marc A, White Ray, Jorgenson Eric

Abstract excerpt

BACKGROUND: Common variants in the CHRNA5-A3-B4 gene cluster have been shown to be associated with nicotine dependence and alcohol use disorders (AUDs) and related traits, including the level of response (LR) to alcohol. Recently, rare variants (MAF < 0.05) in CHRNB4 have been reported to be associated with a decreased risk of developing nicotine dependence. However, the role of rare variants in the CHRNA5-A3-B4...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23458267
DOI: 10.1111/acer.12099

Genes

CHRNA5
CHRNB4
MAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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