Article
Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth.
Proceedings of the National Academy of Sciences of the United States of America - 26 Mar 2013
Schmid Bettina, Hruscha Alexander, Hogl Sebastian, Banzhaf-Strathmann Julia, Strecker Katrin, van der Zee Julie, Teucke Mathias, Eimer Stefan, Hegermann Jan, Kittelmann Maike, Kremmer Elisabeth, Cruts Marc, Solchenberger Barbara, Hasenkamp Laura, van Bebber Frauke, Van Broeckhoven Christine, Edbauer Dieter, Lichtenthaler Stefan F, Haass Christian
Abstract excerpt
Mutations in the Tar DNA binding protein of 43 kDa (TDP-43; TARDBP) are associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43(+) inclusions (FTLD-TDP). To determine the physiological function of TDP-43, we knocked out zebrafish Tardbp and its paralogue Tardbp (TAR DNA binding protein-like), which lacks the glycine-rich domain where ALS- and FTLD-TDP-associated...
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