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Article

Progranulin is neurotrophic in vivo and protects against a mutant TDP-43 induced axonopathy.

PloS one - 13 Oct 2010

Laird Angela S, Van Hoecke Annelies, De Muynck Louis, Timmers Mieke, Van den Bosch Ludo, Van Damme Philip, Robberecht Wim

Abstract excerpt

Mislocalization, aberrant processing and aggregation of TAR DNA-binding protein 43 (TDP-43) is found in the neurons affected by two related diseases, amyotrophic lateral sclerosis (ALS) and frontotemporal lobe dementia (FTLD). These TDP-43 abnormalities are seen when TDP-43 is mutated, such as in familial ALS, but also in FTLD, caused by null mutations in the progranulin gene. They are also found in many patients...

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Identifiers

PMID: 20967127
DOI: 10.1371/journal.pone.0013368
PMCID: PMC2954192

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Progranulin is neurotrophic in vivo and protects against a mutant TDP-43 induced axonopathy.PMID 20967127Read ↗

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