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Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis.

Acta neuropathologica - 1 Apr 2010

Kraemer Brian C, Schuck Theresa, Wheeler Jeanna M, Robinson Linda C, Trojanowski John Q, Lee Virginia M Y, Schellenberg Gerard D

Abstract excerpt

Abnormal TDP-43 aggregation is a prominent feature in the neuropathology of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. Mutations in TARDBP, the gene encoding TDP-43, cause some cases of ALS. The normal function of TDP-43 remains incompletely understood. To better understand TDP-43 biology, we generated mutant mice carrying a genetrap disruption of Tardbp. Mice homozygous for loss...

Topics

Amyotrophic Lateral Sclerosis
Animals
DNA-Binding Proteins
Embryonic Development
Forelimb
Hand Strength
Heterozygote
Mice
Mice, Inbred C57BL
Motor Activity
Motor Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscle, Skeletal

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 20198480
DOI: 10.1007/s00401-010-0659-0
PMCID: PMC2880609

Genes

TARDBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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