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Article

Tardbpl splicing rescues motor neuron and axonal development in a mutant tardbp zebrafish.

Human molecular genetics - 15 Jun 2013

Hewamadduma Channa A A, Grierson Andrew J, Ma Taylur P, Pan Luyuan, Moens Cecilia B, Ingham Philip W, Ramesh Tennore, Shaw Pamela J

Abstract excerpt

Mutations in the transactive response DNA binding protein-43 (TARDBP/TDP-43) gene, which regulates transcription and splicing, causes a familial form of amyotrophic lateral sclerosis (ALS). Here, we characterize and report the first tardbp mutation in zebrafish, which introduces a premature stop codon (Y220X), eliminating expression of the Tardbp protein. Another TARDBP ortholog, tardbpl, in zebrafish is shown to...

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Identifiers

PMID: 23427147
DOI: 10.1093/hmg/ddt082
PMCID: PMC3658164

Genes

TARDBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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