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Article

Tar DNA-binding protein-43 (TDP-43) regulates axon growth in vitro and in vivo.

Neurobiology of disease - 1 May 2014

Tripathi Vineeta Bhasker, Baskaran Pranetha, Shaw Christopher E, Guthrie Sarah

Abstract excerpt

Intracellular inclusions of the TAR-DNA binding protein 43 (TDP-43) have been reported in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD-TDP). Rare mutations in TARDBP have been linked to both ALS and FTD-TDP suggesting that TDP-43 dysfunction is mechanistic in causing disease. TDP-43 is a predominantly nuclear protein with roles in regulating RNA transcription, splicing, stability and...

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Source

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Identifiers

PMID: 24423647
DOI: 10.1016/j.nbd.2014.01.004
PMCID: PMC3988849

Genes

TARDBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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