Article
Alternate pathways for Bcl6-mediated regulation of B cell to plasma cell differentiation.
European journal of immunology - 1 Aug 2011
Alinikula Jukka, Nera Kalle-Pekka, Junttila Sini, Lassila Olli
Abstract excerpt
The transcription factor Bcl6 regulates germinal center formation and differentiation of B cells into high-affinity antibody-producing plasma cells. The direct double-negative regulatory circuit between Bcl6 and Blimp-1 is well established. We now reveal alternative mechanisms for Bcl6-mediated regulation of B-cell differentiation to plasma cells and show with DT40 cells that Bcl6 directly promotes the expression...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
