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Article

Control of Inflammation, Cytokine Expression, and Germinal Center Formation by BCL-6

25 Apr 1997

Abstract excerpt

The gene encoding the BCL-6 transcriptional repressor is frequently translocated and mutated in diffuse large cell lymphoma. Mice with a disrupted BCL-6 gene developed myocarditis and pulmonary vasculitis, had no germinal centers, and had increased expression of T helper cell type 2 cytokines. The BCL-6 DNA recognition motif resembled sites bound by the STAT (signal transducers and activators of transcription)...

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Identifiers

PMID: 9110977
DOI: 10.1126/science.276.5312.589

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