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Article

Host b7x promotes pulmonary metastasis of breast cancer.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2013

Abadi Yael M, Jeon Hyungjun, Ohaegbulam Kim C, Scandiuzzi Lisa, Ghosh Kaya, Hofmeyer Kimberly A, Lee Jun Sik, Ray Anjana, Gravekamp Claudia, Zang Xingxing

Abstract excerpt

B7x (B7-H4 or B7S1) is an inhibitory member of the B7 family of T cell costimulation. It is expressed in low levels in healthy peripheral tissues, such as the lung epithelium, but is overexpressed in a variety of human cancers with negative clinical associations, including metastasis. However, the function of B7x in the context of cancer, whether expressed on cancer cells or on surrounding "host" tissues, has not...

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Identifiers

PMID: 23455497
DOI: 10.4049/jimmunol.1202439
PMCID: PMC3608819

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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