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Article

The B7 Family and Cancer Therapy: Costimulation and Coinhibition

15 Sept 2007

Abstract excerpt

The activation and development of an adaptive immune response is initiated by the engagement of a T-cell antigen receptor by an antigenic peptide-MHC complex. The outcome of this engagement is determined by both positive and negative signals, costimulation and coinhibition, generated mainly by the interaction between the B7 family and their receptor CD28 family. The importance of costimulation and coinhibition of...

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PMID: 17875755
DOI: 10.1158/1078-0432.ccr-07-1030

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