Article
Hoxb7 inhibits transgenic HER-2/neu-induced mouse mammary tumor onset but promotes progression and lung metastasis.
Cancer research - 15 May 2008
Chen Hexin, Lee Ji Shin, Liang Xiaohui, Zhang Huiping, Zhu Tao, Zhang Zhe, Taylor M Evangeline, Zahnow Cynthia, Feigenbaum Lionel, Rein Alan, Sukumar Saraswati
Abstract excerpt
Our previous studies have shown that HOXB7 mRNA is overexpressed in approximately 50% of invasive breast carcinomas and promotes tumor progression in breast cancer cells grown as xenografts in mice. In silico analysis of published microarray data showed that high levels of HOXB7 predict a poor outcome in HER-2-positive (P = 0.046), but not in HER-2-negative breast cancers (P = 0.94). To study the function of...
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