Article
B7-H4 gene polymorphisms are associated with sporadic breast cancer in a Chinese Han population.
BMC cancer - 11 Nov 2009
Zhang Jie, Zhang Mingyan, Jiang Wei, Wang Lihong, Fu Zhenkun, Li Dalin, Pang Da, Li Dianjun
Abstract excerpt
BACKGROUND: B7-H4, a co-inhibitory molecule of the B7 family, can restrain T cell proliferation, cytokine secretion and the development of cytotoxicity. B7-H4 is expressed in tumor tissues at a higher level than in normal tissues, and has a potential effect to protect tumors from anti-tumor immun...
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