Article
Recognition and cleavage of a nonstructured CRISPR RNA by its processing endoribonuclease Cas6.
Structure (London, England : 1993) - 5 Mar 2013
Shao Yaming, Li Hong
Abstract excerpt
Clustered regularly interspaced short palindromic repeats (CRISPRs) confer adaptive immunity to prokaryotes through a small RNA-mediated mechanism. Specific endoribonucleases are required by all CRISPR-bearing organisms to process CRISPR RNAs into small RNA that serve as guides for defensive effector complexes. The molecular mechanism of how the endoribonucleases process the class of CRISPR RNA containing no...
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