Article
Seeing mutations in living cells.
Current biology : CB - 24 Aug 2010
Elez Marina, Murray Andrew W, Bi Li-Jun, Zhang Xian-En, Matic Ivan, Radman Miroslav
Abstract excerpt
BACKGROUND: Evolution depends on mutations: rare errors in the transmission of genetic information. Experimentally, mutations have been found by detecting altered phenotypes or sequencing complete genomes, but most mutations do not have overt phenotypes, and sequencing is expensive and has limited time resolution. The major source of mutations is DNA replication errors. Nearly all mistakes in DNA replication are...
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