Article
HLA-DP and IL28B polymorphisms: influence of host genome on hepatitis B surface antigen seroclearance in chronic hepatitis B.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Jun 2013
Seto Wai-Kay, Wong Danny Ka-Ho, Kopaniszen Malgorzata, Proitsi Petroula, Sham Pak-Chung, Hung Ivan Fan-Ngai, Fung James, Lai Ching-Lung, Yuen Man-Fung
Abstract excerpt
BACKGROUND: The roles of single-nucleotide polymorphisms (SNPs) at HLA-DP and IL28B loci on hepatitis B surface antigen (HBsAg) seroclearance in chronic hepatitis B (CHB) infection are unknown. METHODS: We compared the HLA-DP (rs3077, rs9277378, rs3128917) and IL28B (rs12979860, rs8099917) polymorphisms of 203 CHB patients achieving spontaneous HBsAg seroclearance with 203 age- and sex-matched CHB patients...
