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Article

Genetic Determinants of Spontaneous Hepatitis B Surface Antigen Seroclearance and Its Associated Viral Markers.

Alimentary pharmacology & therapeutics - 1 Jul 2026

Tao Jun, Huang Chih-Jen, Huang Yu-Han, Pan Mei-Hung, Lee Mei-Hsuan, Yu Kelly J, Wang Kevin, Zhu Bin, Hildesheim Allan, Chen Chien-Jen, Yang Hwai-I, Liu Zhiwei

Abstract excerpt

BACKGROUND: Chronic hepatitis B virus (HBV) rarely leads to spontaneous hepatitis B surface antigen (HBsAg) seroclearance. However, host genetics contributing to this outcome remain poorly understood. We investigate genetic variants associated with HBsAg seroclearance and related viral markers. METHODS: We conducted GWAS in 3240 REVEAL-HBV participants to identify SNPs/HLA variants associated with HBV DNA load,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42108971
DOI: 10.1111/apt.70678

Genes

CAMK1D
CTNNB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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