Host genetic factors affecting spontaneous HBsAg seroclearance in chronic hepatitis B patients.

doi:10.1371/journal.pone.0053008

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Article

Host genetic factors affecting spontaneous HBsAg seroclearance in chronic hepatitis B patients.

PloS one - 1 Jan 2013

Cheng Huei-Ru, Liu Chun-Jen, Tseng Tai-Chung, Su Tung-Hung, Yang Hwai-I, Chen Chien-Jen, Kao Jia-Horng

Abstract excerpt

Spontaneous clearance of hepatitis B surface antigen (HBsAg) in chronic hepatitis B (CHB) patients usually indicates a remission of hepatitis activity and a favorable outcome. Two single nucleotide polymorphisms (SNP), rs3077 near HLA-DPA1 region and rs9277535 near HLA-DPB1 region, have been shown to be associated with HBV persistence after acute HBV infection. However, little is known about the impact of these 2...

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Hepatitis B, Chronic
Hepatitis B Surface Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hepatitis B virus

HLA-DP alpha-Chains

HLA-DP beta-Chains

Host-Pathogen Interactions

Linkage Disequilibrium

Odds Ratio

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PMID: 23326374
DOI: 10.1371/journal.pone.0053008
PMCID: PMC3543438

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