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Article

The role of EGF receptor ubiquitination in regulating its intracellular traffic.

Traffic (Copenhagen, Denmark) - 1 Feb 2012

Eden Emily R, Huang Fangtian, Sorkin Alexander, Futter Clare E

Abstract excerpt

Progression of activated EGF receptor (EGFR) through the endocytic pathway regulates EGFR signaling. Here we show that a non-ubiquitinated EGFR mutant, unable to bind the endosomal-sorting complex required for transport (ESCRT) component, Hrs, is not efficiently targeted onto intraluminal vesicles (ILVs) of multivesicular endosomes/bodies (MVBs). Moreover, ubiquitination and ESCRT engagement of activated EGFR are...

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Source

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Identifiers

PMID: 22017370
DOI: 10.1111/j.1600-0854.2011.01305.x
PMCID: PMC3261333

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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