Mutually dependent response elements in the cis-regulatory region of the neurotensin/neuromedin N gene integrate environmental stimuli in PC12 cells.

doi:10.1016/0896-6273(90)90205-t

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Article

Mutually dependent response elements in the cis-regulatory region of the neurotensin/neuromedin N gene integrate environmental stimuli in PC12 cells.

Neuron - 1 May 1990

Kislauskis E, Dobner P R

Abstract excerpt

The expression of the gene encoding the neuroendocrine peptides neurotensin (NT) and neuromedin N is strictly dependent on simultaneous exposure to multiple inducers in PC12 pheochromocytoma cells. NT peptide and NT/N mRNA levels are synergistically induced by combinations of NGF, dexamethasone,...

Topics

Adrenal Gland Neoplasms
Amino Acid Sequence
Animals
Base Sequence
Chromosome Mapping
Fibroblasts
Gene Expression
Genes, Regulator
Molecular Sequence Data
Neurotensin
Peptide Fragments
Phenotype
Pheochromocytoma
Pituitary Gland
Promoter Regions, Genetic
Rats
Tumor Cells, Cultured

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PMID: 2344411
DOI: 10.1016/0896-6273(90)90205-t

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2344411-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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