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Neurotensin , a novel target of Wnt/β‐catenin pathway, promotes growth of neuroendocrine tumor cells

5 Aug 2014

Abstract excerpt

Wnt/β-catenin signaling plays a pivotal role in regulating cell growth and differentiation by activation of the β-catenin/T-cell factor (TCF) complex and subsequent regulation of a set of target genes that have one or more TCF-binding elements (TBEs). Hyperactivation of this pathway has been implicated in numerous malignancies including human neuroendocrine tumors (NETs). Neurotensin (NT), an intestinal hormone,...

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PMID: 25098665
DOI: 10.1002/ijc.29123

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