Article
Cyclic adenosine 5'-monophosphate-stimulated neurotensin secretion is mediated through Rap1 downstream of both Epac and protein kinase A signaling pathways.
Molecular endocrinology (Baltimore, Md.) - 1 Jan 2007
Li Jing, O'Connor Kathleen L, Cheng Xiaodong, Mei Fang C, Uchida Tatsuo, Townsend Courtney M, Evers B Mark
Abstract excerpt
Neurotensin (NT), a gut peptide, plays important roles in gastrointestinal secretion, inflammation, and growth of normal and neoplastic tissues. cAMP regulates the secretion of hormones via its effector proteins protein kinase A (PKA) or Epac (exchange protein directly activated by cAMP). The small GTPase Rap1 can be activated by both PKA and Epac; however, the role of Rap1 in hormone secretion is unknown. Here,...
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