Article
The CRE-like element inside the 5'-upstream region of the rat sodium/iodide symporter gene interacts with diverse classes of b-Zip molecules that regulate transcriptional activities through strong synergy with Pax-8.
Molecular endocrinology (Baltimore, Md.) - 1 Nov 2004
Chun J T, Di Dato V, D'Andrea B, Zannini M, Di Lauro R
Abstract excerpt
We previously demonstrated that transcription of the rat sodium/iodide symporter (NIS) gene is regulated by NUE, an upstream enhancer located between nucleotides -2264 and -2495 of the 5'-flanking region. To elucidate the mechanism of TSH/cAMP-mediated regulation of NIS gene expression, we have characterized the putative cAMP response element (CRE)/activator protein (AP)-1 site (termed NUC) that is closely...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.