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Article

Regulation of spine density and morphology by IQGAP1 protein domains.

PloS one - 1 Jan 2013

Jausoro Ignacio, Mestres Ivan, Quassollo Gonzalo, Masseroni Lujan, Heredia Florencia, Caceres Alfredo

Abstract excerpt

IQGAP1 is a scaffolding protein that regulates spine number. We now show a differential role for IQGAP1 domains in spine morphogenesis, in which a region of the N-terminus that promotes Arp2/3-mediated actin polymerization and branching stimulates spine head formation while a region that binds to Cdc42 and Rac is required for stalk extension. Conversely, IQGAP1 rescues spine deficiency induced by expression of...

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Source

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Identifiers

PMID: 23441206
DOI: 10.1371/journal.pone.0056574
PMCID: PMC3575492

Genes

IQGAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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