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Article

Sema4D-plexin-B1 implicated in regulation of dendritic spine density through RhoA/ROCK pathway.

Neuroscience letters - 20 Nov 2007

Lin Xianzong, Ogiya Mariko, Takahara Mizue, Yamaguchi Wataru, Furuyama Tatsuo, Tanaka Hidekazu, Tohyama Masaya, Inagaki Shinobu

Abstract excerpt

Plexin-B1, Sema4D receptor, mediates retraction and extension signals in axon guidance by associating with PDZ-containing Rho guanine nucleotide exchange factors (PDZ-RhoGEFs) which can activate a small Rho GTPase RhoA. RhoA is implicated in spine formation by rearranging actin cytoskeleton. Exogenous application of Sema4D to cultured neurons caused activation of RhoA, increase of spine density and changes in...

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Identifiers

PMID: 17950529
DOI: 10.1016/j.neulet.2007.09.045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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