Article
Neuron-enriched phosphatase and actin regulator 3 (Phactr3)/ nuclear scaffold-associated PP1-inhibiting protein (Scapinin) regulates dendritic morphology via its protein phosphatase 1-binding domain.
Biochemical and biophysical research communications - 23 Jul 2020
Miyata Tomoaki, Kikuchi Keietsu, Ihara Daisuke, Kaito Maki, Ishibashi Yuta, Hakamata Tomoyuki, Yamada Tetsuya, Ishikawa Mitsuru, Mizukoshi Miho, Shoji Shizuku, Fukuchi Mamoru, Tsuda Masaaki, Hida Yamato, Ohtsuka Toshihisa, Kaneda Marisa, Tabuchi Akiko
Abstract excerpt
Phosphatase and actin regulator 3/nuclear scaffold-associated protein phosphatase 1-inhibiting protein (Phactr3/Scapinin) is an actin- and protein phosphatase 1 (PP1)-binding protein known to negatively regulate axon elongation. In this study, we examined the expression pattern of Phactr3/Scapinin in several tissues and investigated the effect of Phactr3/Scapinin on dendritic morphology of cortical neurons....
Topics
- Animals
- Cerebral Cortex
- Dendrites
- Female
- Male
- Mice, Inbred C57BL
- Microfilament Proteins
- Mutation
- Nuclear Matrix