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Article

Synapse formation is regulated by the signaling adaptor GIT1.

The Journal of cell biology - 14 Apr 2003

Zhang Huaye, Webb Donna J, Asmussen Hannelore, Horwitz Alan F

Abstract excerpt

Dendritic spines in the central nervous system undergo rapid actin-based shape changes, making actin regulators potential modulators of spine morphology and synapse formation. Although several potential regulators and effectors for actin organization have been identified, the mechanisms by which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12695502
DOI: 10.1083/jcb.200211002
PMCID: PMC2172873

Genes

GIT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12695502-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Synapse formation is regulated by the signaling adaptor GIT1.PMID 12695502Read ↗

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The planar polarity protein Scribble1 is essential for neuronal plasticity and brain function.Semantic proximity Read ↗

The Drosophila homologue of Arf-GAP GIT1, dGIT, is required for proper muscle morphogenesis and guidance during embryogenesis.Semantic proximity Read ↗

Interaction of Cupidin/Homer2 with two actin cytoskeletal regulators, Cdc42 small GTPase and Drebrin, in dendritic spines.Semantic proximity Read ↗

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Identification of an intramolecular interaction important for the regulation of GIT1 functions.Semantic proximity Read ↗

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