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Article

Gene expression and thiopurine metabolite profiling in inflammatory bowel disease - novel clues to drug targets and disease mechanisms?

PloS one - 1 Jan 2013

Haglund Sofie, Almer Sven, Peterson Curt, Söderman Jan

Abstract excerpt

BACKGROUND AND AIMS: Thiopurines are effective to induce and maintain remission in inflammatory bowel disease (IBD). The methyl thioinosine monophosphate (meTIMP)/6-thioguanine nucleotide (6-TGN) concentration ratio has been associated with drug efficacy. Here we explored the molecular basis of differences in metabolite profiles and in relation to disease activity. METHODS: Transcriptional profiles in blood...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23437289
DOI: 10.1371/journal.pone.0056989
PMCID: PMC3578787

Genes

CTSS
DEF8
HVCN1
NME6
PLCB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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