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Article

The role of inosine-5'-monophosphate dehydrogenase in thiopurine metabolism in patients with inflammatory bowel disease.

Therapeutic drug monitoring - 1 Apr 2011

Haglund Sofie, Vikingsson Svante, Söderman Jan, Hindorf Ulf, Grännö Christer, Danelius Margareta, Coulthard Sally, Peterson Curt, Almer Sven

Abstract excerpt

BACKGROUND: There is a large interindividual variability in thiopurine metabolism. High concentrations of methylthioinosine-5'-monophosphate (meTIMP) and low concentrations of 6-thioguanine nucleotides (6-TGNs) have been associated with a lower response rate and an increased risk of adverse events. In this study, the role of inosine-5'-monophosphate dehydrogenase (IMPDH) for differences in metabolite patterns of...

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Source

Identifiers

PMID: 21311411
DOI: 10.1097/FTD.0b013e31820b42bb

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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