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Article

An SRF/miR-1 axis regulates NCX1 and annexin A5 protein levels in the normal and failing heart.

Cardiovascular research - 1 Jun 2013

Tritsch Eva, Mallat Youssef, Lefebvre Florence, Diguet Nicolas, Escoubet Brigitte, Blanc Jocelyne, De Windt Leon J, Catalucci Daniele, Vandecasteele Grégoire, Li Zhenlin, Mericskay Mathias

Abstract excerpt

AIMS: The expression of the sodium/calcium exchanger NCX1 increases during cardiac hypertrophy and heart failure, playing an important role in Ca(2+) extrusion. This increase is presumed to result from stress signalling induced changes in the interplay between transcriptional and post-transcriptional regulations. We aimed to determine the impact of the SRF transcription factor known to regulate the NCX1 promoter...

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Source

Identifiers

PMID: 23436819
DOI: 10.1093/cvr/cvt042

Genes

SRF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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