Article

The Calcineurin-FoxO-MuRF1 Signaling Pathway Regulates Myofibril Integrity in Cardiomyocytes

2017-04-25

Abstract excerpt

Altered Ca 2+ handling is often present in diseased hearts undergoing structural remodeling and functional deterioration. The influences of Ca 2+ signaling on cardiac function have been examined extensively, but whether Ca 2+ directly regulates sarcomere structure has remained elusive. Using a mutant zebrafish model lacking NCX1 activity in the heart, we explored the impacts of impaired Ca 2+ homeostasis on m...

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Literature Corpus work: 3f9f6bc2-72a1-5c4f-9ec6-2a288ee5f566
DOI: 10.1101/130831

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