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Article

Sarcoplasmic reticulum Ca<sup>2+</sup>ATPase as a therapeutic target for heart failure

9 Dec 2009

Abstract excerpt

The cardiac isoform of the sarco/endoplasmic reticulum Ca(2+)ATPase (SERCA2a) plays a major role in controlling excitation/contraction coupling. In both experimental and clinical heart failure, SERCA2a expression is significantly reduced which leads to abnormal Ca(2+) handling and deficient contractility. A large number of studies in isolated cardiac myocytes and in small and large animal models of heart failure...

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PMID: 20078230
DOI: 10.1517/14712590903321462

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