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Identification of genes involved in the initiation of human Th1 or Th2 cell commitment

11 Oct 2005

Abstract excerpt

The differentiation of naïve T helper (Th) cells is induced by TCR activation and IL-12/STAT4 or IL-4/STAT6 signaling pathways, forming Th1 and Th2 cells, respectively. In this study, oligonucleotide arrays were used to identify genes regulated during the initiation of human Th1 and Th2 cell differentiation at 2 and 6 h in presence or absence of immunosuppressive TGF-beta. As a result the immediate targets of...

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PMID: 16220538
DOI: 10.1002/eji.200526079

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