Article
GATA3 mutations found in breast cancers may be associated with aberrant nuclear localization, reduced transactivation and cell invasiveness.
Hormones & cancer - 1 Jun 2013
Gaynor Katherine U, Grigorieva Irina V, Allen Michael D, Esapa Christopher T, Head Rosemary A, Gopinath Preethi, Christie Paul T, Nesbit M Andrew, Jones J Louise, Thakker Rajesh V
Abstract excerpt
Somatic and germline mutations in the dual zinc-finger transcription factor GATA3 are associated with breast cancers expressing the estrogen receptor (ER) and the autosomal dominant hypoparathyroidism-deafness-renal dysplasia syndrome, respectively. To elucidate the role of GATA3 in breast tumorigenesis, we investigated 40 breast cancers that expressed ER, for GATA3 mutations. Six different heterozygous GATA3...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.