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Article

IGF-1 signaling and aging.

Experimental gerontology - 1 Jan 2000

Holzenberger Martin, Kappeler Laurent, De Magalhaes Filho Carlos

Abstract excerpt

We briefly compare calorie restriction, GHRH-R and Pit-1 mutants with knockout phenotypes of GH receptor, IGF-1 receptor and p66Shc, to make some general conclusions. Growth, fertility and longevity phenotypes may dissociate in some of these mutants, and we try to interpret this. Follows a short discussion on the importance of genetic background for aging studies in mice. We then evoke studies in C. elegans...

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Source

Identifiers

PMID: 15582293
DOI: 10.1016/j.exger.2004.08.017

Genes

GHRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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