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Article

Identification of molecular alterations in gastrointestinal carcinomas and dysplastic hamartomas in Peutz-Jeghers syndrome.

Carcinogenesis - 1 Jul 2013

Korsse Susanne E, Biermann Katharina, Offerhaus G Johan A, Wagner Anja, Dekker Evelien, Mathus-Vliegen Elisabeth M H, Kuipers Ernst J, van Leerdam Monique E, van Veelen Wendy

Abstract excerpt

Peutz-Jeghers syndrome (PJS) is caused by mutations in the LKB1 gene. It is characterized by gastrointestinal polyposis and an increased cancer risk, mainly in the gastrointestinal tract. Mechanisms of PJS-associated carcinogenesis are unclear. We investigated the involvement of candidate genes and molecular pathways in PJS-associated gastrointestinal cancers and dysplastic hamartomas. Cases were selected from...

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Source

Identifiers

PMID: 23430953
DOI: 10.1093/carcin/bgt068

Genes

SMAD4
BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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