Article
Pathogenesis of adenocarcinoma in Peutz-Jeghers syndrome.
Cancer research - 1 Dec 1998
Gruber S B, Entius M M, Petersen G M, Laken S J, Longo P A, Boyer R, Levin A M, Mujumdar U J, Trent J M, Kinzler K W, Vogelstein B, Hamilton S R, Polymeropoulos M H, Offerhaus G J, Giardiello F M
Abstract excerpt
Peutz-Jeghers syndrome (PJS) is an autosomal dominant condition characterized by intestinal hamartomatous polyps, mucocutaneous melanin deposition, and increased risk of cancer. Families with PJS from the Johns Hopkins Polyposis Registry were studied to identify the molecular basis of this syndro...
Topics
- Adenocarcinoma
- Chromosomes, Human, Pair 19
- DNA Mutational Analysis
- Female
- Gastrointestinal Diseases
- Gastrointestinal Neoplasms
- Genetic Linkage
- Germ-Line Mutation
- Hamartoma
- Haplotypes
- Humans
- Loss of Heterozygosity
- Male
- Pedigree