Article
Immunohistological evidence for Wnt-signaling activation in Peutz-Jeghers polyposis.
Pediatric surgery international - 1 Feb 2010
Chaiyapan Walawee, Sangkhathat Surasak, Kanngurn Samornmas, Phukaoloun Monlika, Chiengkriwate Piyawan, Patrapinyokul Sakda
Abstract excerpt
OBJECTIVE: Molecular pathogenesis of gastrointestinal polyposis in Peutz-Jegher's syndrome (PJS) has been linked to the loss-of-function mutation of LKB1. Recent functional genetic studies have pointed out that LKB1 plays a physiological role in controlling the Wnt-signaling pathway and activatio...
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