Article
Peutz-Jeghers syndrome: a systematic review and recommendations for management.
Gut - 1 Jul 2010
Beggs A D, Latchford A R, Vasen H F A, Moslein G, Alonso A, Aretz S, Bertario L, Blanco I, Bülow S, Burn J, Capella G, Colas C, Friedl W, Møller P, Hes F J, Järvinen H, Mecklin J-P, Nagengast F M, Parc Y, Phillips R K S, Hyer W, Ponz de Leon M, Renkonen-Sinisalo L, Sampson J R, Stormorken A, Tejpar S, Thomas H J W, Wijnen J T, Clark S K, Hodgson S V
Abstract excerpt
Peutz-Jeghers syndrome (PJS, MIM175200) is an autosomal dominant condition defined by the development of characteristic polyps throughout the gastrointestinal tract and mucocutaneous pigmentation. The majority of patients that meet the clinical diagnostic criteria have a causative mutation in the STK11 gene, which is located at 19p13.3. The cancer risks in this condition are substantial, particularly for breast...
Topics
- Adult
- Aged
- Breast Neoplasms
- Child
- Child, Preschool
- Endoscopy, Gastrointestinal
- Evidence-Based Medicine
- Female
- Gastrointestinal Neoplasms