Article
Mucosal prolapse in the pathogenesis of Peutz-Jeghers polyposis.
Gut - 1 Jan 2006
Jansen M, de Leng W W J, Baas A F, Myoshi H, Mathus-Vliegen L, Taketo M M, Clevers H, Giardiello F M, Offerhaus G J A
Abstract excerpt
Germline mutations in LKB1 cause the rare cancer prone disorder Peutz-Jeghers syndrome (PJS). Gastrointestinal hamartomatous polyps constitute the major phenotypic trait in PJS. Hamartomatous polyps arising in PJS patients are generally considered to lack premalignant potential although rare neoplastic changes in these polyps and an increased gastrointestinal cancer risk in PJS are well documented. These...
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